We present a case of systemic lupus erythematosus (SLE), which was diagnosed before 7 years, and antirheumatic therapy was prescribed. However, following relief of the initial symptoms, the patient stopped taking medications and presented again, after being symptom-free for three years, with chylothorax and symptoms, which were entirely different from the first visit. The patient was treated with a combination of hydroxychloroquine, prednisolone and azathioprine following ruling out of malignancy and infections and responded well to the therapy.
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