Intraarticular therapy with hyaluronic acid and platelet-rich plasma in hip OA – modern aspects
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intraarticular therapy, hip osteoarthritis, hyaluronic acid, platelet-rich plasma

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Sapundzhiev, L., Sapundzhieva, T., Klinkanov, K., & Batalov, A. (2021). Intraarticular therapy with hyaluronic acid and platelet-rich plasma in hip OA – modern aspects. Rheumatology (Bulgaria), 29(4), 53-86.


Intraarticular therapy in ОА, particularly in НОА, is very important, as it is directly targeting the problematic joint, affording stable therapeutic concentrations in situ to be maintained with minimal systemic and adverse effects of the administrated drugs. The presented review consists of 2 parts: descriptive and systematic analysis. In the first part mechanisms of action, indications, contraindications, methods of administration and adverse effects of the intraarticular therapy with hyaluronic acid (IA-HA) and with platelet-rich plasma (IAPRP) are presented, as well as the official statements of the major rheumatologic organizations (EULAR; ACR; OARSI), concerning this issue. In the systemic reviews 34 original studies on IA-НА in  НОА and 7 original studies on IA-PRP in НОА are analysed. The data of rapidity, expression and sustainability of the effects of IA-HA/IA-PRP are assessed by meta analyses, the obtained results are compared to those from the open 8 descriptive and 8 systemic reviews of foreign authors.

In the discussion the different interpretations of the results from the original studies and preceding meta analyses are pointed out according to the authors’ opinion.
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