Clinical Case of a Patient with Multiple Sclerosis, Polymyositis and Melanoma. Is There a Connection Between Them?

Abstract

Background: We present a case of a patient with the sequential development of clinical symptoms characteristic of multiple sclerosis, polymyositis, and malignant melanoma. Case presentation: Polymyositis occurred two years after the onset of multiple sclerosis. Clinical signs of melanoma were identified following the development of polymyositis. Treatment with corticosteroids and immunosuppressants positively affected the patient’s clinical manifestations of multiple sclerosis. It remains unclear whether there was an insidious progression of melanoma without clinical manifestations and whether the myositis developed in parallel with this melanoma. It is possible that polymyositis developed independently or preceded the onset of melanoma with lymph node metastases. Conclusion: The patient's clinical history demonstrates an overlap of demyelinating, systemic, and malignant diseases. Integrated treatment is essential for achieving clinical improvement in these patients.